A Handbook of Bioanalysis and Drug.pdf

A HANDBOOK OF

BIOANALYSIS AND

DRUG

METABOLISM

BIOANALYSIS AND

DRUG

METABOLISM

E DITED BY

Gary Evans

CRC PRESS

Boca Raton London New York Washington, D.C.

A HANDBOOK OF

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Contents

Editor’s preface

Preface

Grieves Harnby: In memoriam

CHAPTER 1 Introduction

Gary Evans

1.1 Bioanalysis, pharmacokinetics and drug

metabolism (BPDM)

1.2 The role of BPDM in drug discovery and drug

development

CHAPTER 2 The importance of the physicochemical

properties of drugs to drug metabolism

David Spalding

2.1 Introduction

2.2 The physicochemical nature of drug molecules

2.3 The structure of the cell membrane and its

implications for drug disposition

2.4 Drug partitioning across membranes

2.5 The ionisation of drugs

2.6 The pH environment of the body and how it affects

drug absorption and distribution

2.7 The importance of the physicochemical properties of

drugs to their metabolism and excretion

2.8 Chirality and its effects on drug absorption,

metabolism and excretion

2.9 The importance of physicochemical properties to the

analysis of drugs

2.10 Summary

2.11 Bibliography

CHAPTER 3 Sample preparation

Bob Biddlecombe and Glenn Smith

3.1 Introduction

3.2 Sample preparation techniques

3.3 Instrumentation

3.4 Bioanalytical automation strategy

3.5 Future development

3.6 References

CHAPTER 4 High-performance liquid

chromatography in pharmaceutical

bioanalysis

David N. Mallett

4.1 Introduction

4.2 A brief look at the theory of chromatographic

separation in HPLC

4.3 The basic equipment comprising a modern HPLC system

4.4 Modes of liquid chromatography

4.5 High-throughput bioanalysis

4.6 Chiral HPLC

4.7 Future trends in HPLC

4.8 Bibliography

CHAPTER 5 Mass spectrometry and quantitative

bioanalysis

Bob Biddlecombe, Sheryl Callejas and Gary Evans

5.1 Introduction

5.2 The instruments

5.3 Analytical interfaces

5.4 Ionisation

5.5 Mass analysers

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