[01-0103] Bio-Tech(1).pdf

Written by DAVID MORGAN-MAR and DAVID PULVER

Additional Material by WILLIAM BARTON, ERIC FUNK, STEVE JACKSON,

and WILLIAM H. STODDARD

Edited by WILLIAM H. STODDARD

Cover Art by ABRAR AJMAL and BOB STEVLIC

Illustrated by ABRAR AJMAL, CHRIS QUILLIAMS, CHRISTOPHER SHY,

BOB STEVLIC, and EVA WIDERMANN

STEVE JACKSON GAMES

Stock #31-0103

Version 1.0 – February 15, 2007

I NTRODUCTION . . . . . . . . . . . 4

About the Authors . . . . . . . . . . . . . . . . 4

About GURPS . . . . . . . . . . . . . . . . . . . 4

1. B IOTECHNOLOGY . . . . . . . 5

B ASIC P RINCIPLES . . . . . . . . . . . . . . . . . 6

Mendelian Heredity . . . . . . . . . . . . . . . 6

DNA S EQUENCING . . . . . . . . . . . . . . . . 7

The Human Genome Project. . . . . . . . 8

DNA Testing Procedures . . . . . . . . . . 8

S ELECTIVE B REEDING . . . . . . . . . . . . . 10

G ENETIC E NGINEERING . . . . . . . . . . . 11

Genetic Engineering Procedures. . . 12

Gene Cloning . . . . . . . . . . . . . . . . . . . 12

Germline Gengineering . . . . . . . . . . 13

Horizontal Gene Transfer . . . . . . . . . 13

Self-Modifying Genetic Code. . . . . . 14

Genetic Surgery. . . . . . . . . . . . . . . . . 14

Genetic Reconstruction . . . . . . . . . . 14

Biotech Facilities. . . . . . . . . . . . . . . . 15

Bioengineering Equipment . . . . . . . . 15

Genetic Engineering in Play . . . . . . 17

R EPRODUCTIVE T ECHNOLOGY . . . . . . 19

Birth Control . . . . . . . . . . . . . . . . . . . 19

Fertility Treatments . . . . . . . . . . . . . 19

Surrogate Motherhood. . . . . . . . . . . 20

Growth Tanks . . . . . . . . . . . . . . . . . . 20

Stem Cells . . . . . . . . . . . . . . . . . . . . . . 22

C LONING . . . . . . . . . . . . . . . . . . . . . . . . . 22

The History of Cloning. . . . . . . . . . . 22

Clones and Uniqueness . . . . . . . . . . 23

Utility of Post-Embryonic Cloning . . 24

Risks of Cloning . . . . . . . . . . . . . . . . . 24

B IOMETRICS . . . . . . . . . . . . . . . . . . . . . . 24

A RTIFICIAL L IFE . . . . . . . . . . . . . . . . . . .26

Tissue Engineering . . . . . . . . . . . . . . 26

Mimicking Biology . . . . . . . . . . . . . . 26

Lifebanks and Genome Libraries . . . 27

B IOMATERIALS . . . . . . . . . . . . . . . . . . . 28

Biomimetics. . . . . . . . . . . . . . . . . . . . 28

Biotronics. . . . . . . . . . . . . . . . . . . . . . 28

V ARIANT B IOTECH . . . . . . . . . . . . . . . . 30

Magical Biotech . . . . . . . . . . . . . . . . 30

Imprinting . . . . . . . . . . . . . . . . . . . . . 30

Steampunk Biotech . . . . . . . . . . . . . 33

Biotech Development Pathways . . . . 33

Horror Biotech . . . . . . . . . . . . . . . . . 35

Different Biologies . . . . . . . . . . . . . . . 35

2. H UMAN G ENETIC

E NGINEERING . . . . . . . . 36

G ENGINEERING AT C ONCEPTION . . . . 36

Eugenic Germline Gengineering. . . 36

Germline Gengineering

for Species Modification . . . . . . 37

Genetic Engineering

and Other Species . . . . . . . . . . . 37

Alien Hybrids . . . . . . . . . . . . . . . . 38

Objectives of

Human Gengineering . . . . . . . 38

Why Make Übermenschen? . . . . 39

Hidden Dangers . . . . . . . . . . . . . 40

Nature Versus Nurture . . . . . . . . . 40

Designing Variant Humans . . . . 41

Experimental Procedures . . . . . . . . 41

G ENGINEERED T RAITS . . . . . . . . . . . . 42

Brain Modifications . . . . . . . . . . . . . 42

Cardiovascular Modifications . . . . . 44

Cosmetic and Minor

Transgenic Modifications . . . . . 44

Digestive and

Filtration Modifications . . . . . . . 46

Glandular Modifications . . . . . . . . . 47

Immune System Modifications . . . . 49

Lifespan and Self-Repair

Modifications. . . . . . . . . . . . . . . . 50

Morphological Changes . . . . . . . . . . 51

Musculo-Skeletal Modifications . . . 53

Nervous System Modifications . . . . 54

Respiratory Modifications . . . . . . . . 55

Sensory Modifications . . . . . . . . . . . 56

Sexual and Reproductive

Modifications. . . . . . . . . . . . . . . . 58

Sex Ratios . . . . . . . . . . . . . . . . . . . . . . 58

Transformations . . . . . . . . . . . . . . . . 60

Unintended Disadvantages . . . . . . . 61

Bioroid Modifications . . . . . . . . . . . . 61

Size Modification . . . . . . . . . . . . . . . 62

Other Features. . . . . . . . . . . . . . . . . . 64

Beyond the Probable . . . . . . . . . . . . . 65

Racial Point Cost. . . . . . . . . . . . . . . . 65

Life’s Price Tag . . . . . . . . . . . . . . . . . 65

G ENGINEERED H UMAN

R ACIAL T EMPLATES . . . . . . . . . . 66

Genetic Upgrades . . . . . . . . . . . . . . . 66

Homo superior Parahumans . . . . . . 67

Genetic Mixing . . . . . . . . . . . . . . . . . . 68

Pantropic Parahumans. . . . . . . . . . . 70

Specialists and Slaves. . . . . . . . . . . . 72

3. M AN ’ S B EST F RIENDS . . . 75

P ROCESSED B IOPRODUCTS . . . . . . . . . 75

B IOLOGICAL C ONTROL . . . . . . . . . . . . . 76

Control Using Extant Species . . . . . 76

Gengineered Control Species . . . . . 76

Control Using Microorganisms . . . . 76

Environmental Control . . . . . . . . . . 77

P LANT T ECHNOLOGY . . . . . . . . . . . . . . 77

Propagation . . . . . . . . . . . . . . . . . . . . 77

Hydroponics . . . . . . . . . . . . . . . . . . . 78

G ENGINEERED P LANTS . . . . . . . . . . . . 78

Biotech Foodstuffs . . . . . . . . . . . . . . 78

Crop Modifications . . . . . . . . . . . . . . 78

Plants as Materials Producers . . . . . 80

Plant Bioweapons . . . . . . . . . . . . . . . 80

Rapid-Growth Plants . . . . . . . . . . . . 80

Zoogenetic Plants . . . . . . . . . . . . . . . 81

G ENGINEERED F UNGI . . . . . . . . . . . . . 81

G ENGINEERED I NSECTS . . . . . . . . . . . 82

Helpful Insects . . . . . . . . . . . . . . . . . 82

Insect Bioweapons . . . . . . . . . . . . . . 82

Sample Gengineered Insects . . . . . . 84

G ENGINEERED A NIMALS . . . . . . . . . . . 84

Levels of Sapience . . . . . . . . . . . . . . . 85

Creating Biomodified Animals . . . . 86

Animal Modifications . . . . . . . . . . . . 87

Sample Gengineered Animals . . . . . 88

Non-Sapient Animals . . . . . . . . . . . . 93

Industrial and Research Animals . . 93

Symbiotic Parasites . . . . . . . . . . . . . 94

B IOGADGETS . . . . . . . . . . . . . . . . . . . . . 95

Care and Feeding of Biogadgets . . . . 95

Emulating Existing Technology . . . 95

GURPS System Design

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C ONTENTS

Managing Editor

Print Buyers

Page Design

Creating New Gadgets . . . . . . . . . . . 96

Sample Biogadgets . . . . . . . . . . . . . . 96

B IOVEHICLES . . . . . . . . . . . . . . . . . . . . . 96

Designing Biovehicles. . . . . . . . . . . . 96

Spacecraft (Bioships) . . . . . . . . . . . . 98

Airships (Bioblimps). . . . . . . . . . . . . 99

Water Vehicles (Biosubs) . . . . . . . . 100

Other Considerations . . . . . . . . . . . 100

B IOBUILDINGS . . . . . . . . . . . . . . . . . . . 101

Gaia: Planet-Sized Organisms . . . . . 101

4. M ICROORGANISMS . . . . 102

T YPES OF M ICROORGANISMS . . . . . . 102

The Domains of Life . . . . . . . . . . . . 103

I NDUSTRIAL AND

C OMMERCIAL M ICROBES . . . . . 104

Purchasing Microorganisms . . . . . . 105

Energy and Fuel Production . . . . . 105

Mining and Refining . . . . . . . . . . . 106

Corrosion Control . . . . . . . . . . . . . . 106

Pollution Control . . . . . . . . . . . . . . 106

Domestic Bacteria. . . . . . . . . . . . . . 107

Targeted Microbes . . . . . . . . . . . . . 107

Microbial Construction . . . . . . . . . 108

Economic Impact of

Biological Manufacturing . . . . . 108

Bioelectronics . . . . . . . . . . . . . . . . . 108

Sucrochemicals . . . . . . . . . . . . . . . . 109

Terraforming . . . . . . . . . . . . . . . . . . 109

Z OOGLOEAL O RGANISMS . . . . . . . . . 110

Biofilm Growth . . . . . . . . . . . . . . . . 110

Biofilms . . . . . . . . . . . . . . . . . . . . . . 111

Giant Blobs! . . . . . . . . . . . . . . . . . . . 111

G ERM W ARFARE . . . . . . . . . . . . . . . . .112

Ecological Warfare . . . . . . . . . . . . . . 112

Biological Agents . . . . . . . . . . . . . . 112

Cleanup . . . . . . . . . . . . . . . . . . . . . . . 114

Enhanced Germs . . . . . . . . . . . . . . 114

Target-Seeking Pathogens . . . . . . . 115

Designer Plagues. . . . . . . . . . . . . . . 116

Germ Delivery . . . . . . . . . . . . . . . . . 116

Sample New Bacterium:

Oedipus-5 . . . . . . . . . . . . . . . . . . 116

Germ Warfare and Terrorism . . . . . 117

Anti-Germ Warfare . . . . . . . . . . . . . 117

Anti-Material Bacteria . . . . . . . . . . 118

M EDICAL A PPLICATIONS . . . . . . . . . . 119

Fighting Disease . . . . . . . . . . . . . . . 119

Protein Factories. . . . . . . . . . . . . . . 120

Encapsulated Cell Implants. . . . . . 120

Symbiotic Bacteria . . . . . . . . . . . . . 120

5. M EDICAL

T ECHNOLOGY . . . . . . . 122

F IRST A ID . . . . . . . . . . . . . . . . . . . . . . . 123

Stabilization . . . . . . . . . . . . . . . . . . 123

Shock . . . . . . . . . . . . . . . . . . . . . . . . 125

D IAGNOSIS . . . . . . . . . . . . . . . . . . . . . . 125

Medical Treatment . . . . . . . . . . . . . . 125

Vital Signs . . . . . . . . . . . . . . . . . . . . 126

Laboratory Tests . . . . . . . . . . . . . . . 127

Medical Imaging . . . . . . . . . . . . . . . 127

Exploratory Surgery . . . . . . . . . . . . . 127

Monoclonal Antibodies . . . . . . . . . 129

N ON -I NVASIVE P ROCEDURES . . . . . . 130

Blood Transfusion . . . . . . . . . . . . . 130

Blood Types . . . . . . . . . . . . . . . . . . . 130

Non-Surgical Treatments. . . . . . . . 131

“Do You Have Insurance?” . . . . . . . 134

S URGERY AND L IFE S UPPORT . . . . . 135

Anesthesia . . . . . . . . . . . . . . . . . . . . 135

Life Support . . . . . . . . . . . . . . . . . . 136

Surgical Procedures . . . . . . . . . . . . 136

Exploring Inner Space . . . . . . . . . . . 137

Cinematic Surgery . . . . . . . . . . . . . . 138

Recovery. . . . . . . . . . . . . . . . . . . . . . 139

Autopsy . . . . . . . . . . . . . . . . . . . . . . 139

How Fast Does a Body Decay? . . . . 140

M EDICAL T RANSPLANTS . . . . . . . . . . 141

Acquiring Organs . . . . . . . . . . . . . . 141

Rejection and

Immunosuppression. . . . . . . . . 141

Telemedicine . . . . . . . . . . . . . . . . . . . 142

Types of Transplants . . . . . . . . . . . 142

N EUROLOGICAL P ROCEDURES . . . . . 143

P RESERVATION . . . . . . . . . . . . . . . . . . 144

Cryonic Preservation . . . . . . . . . . . 144

Nonhuman

Cryonic Suspension . . . . . . . . . . 145

Suspended Animation . . . . . . . . . . 146

Nanostasis . . . . . . . . . . . . . . . . . . . . 147

Temporal Stasis . . . . . . . . . . . . . . . 147

6. D RUGS AND N ANO . . . . 148

C HEMICAL D RUGS . . . . . . . . . . . . . . . 148

Therapeutic Drugs . . . . . . . . . . . . . 149

Drug Allergies . . . . . . . . . . . . . . . . . . 150

Storage and Handling of

Drugs and Nano . . . . . . . . . . . . 153

Capability-Enhancing Drugs . . 154

Xenodrugs . . . . . . . . . . . . . . . . . . 156

Espionage Drugs. . . . . . . . . . . . 157

Lifestyle Drugs . . . . . . . . . . . . . 157

Longevity Drugs . . . . . . . . . . . . 158

Name That Drug! . . . . . . . . . . . 159

Pharmacogenomic Drugs . . . . 160

Psi Drugs . . . . . . . . . . . . . . . . . . . . . 160

Designing Drugs . . . . . . . . . . . . . . . . 160

Magical and Mystical Drugs . . . . . 161

N ANODRUGS . . . . . . . . . . . . . . . . . . . . 161

Transformational Nano . . . . . . . . . 162

N ANOSYMBIONTS . . . . . . . . . . . . . . . . 164

D RUG AND N ANO

D ELIVERY M ETHODS . . . . . . . . .167

7. B IOMODS . . . . . . . . . . . 168

E LECTIVE S URGERY . . . . . . . . . . . . . . 168

Acquiring Biomods . . . . . . . . . . . . . 169

Bodysculpting . . . . . . . . . . . . . . . . . 169

Biomod Transplants . . . . . . . . . . . . 173

Polykeratin Grafts. . . . . . . . . . . . . . 177

Xenotransplants . . . . . . . . . . . . . . . 178

Neuromods . . . . . . . . . . . . . . . . . . . 179

Genetic Surgery Biomods . . . . . . . 181

The Genetics of Aging . . . . . . . . . . . 183

P ROTEUS N ANOVIRUS . . . . . . . . . . . . 184

Growing Nanovirus . . . . . . . . . . . . 185

Types of Proteus Virus . . . . . . . . . . 185

M ETAMORPHOSIS V IRUS . . . . . . . . . .187

Proteus Virus Options . . . . . . . . . . 190

Nanowarfare . . . . . . . . . . . . . . . . . . 191

8. C HARACTERS AND

S OCIETY . . . . . . . . . . . 192

B IOTECH C ORPORATIONS . . . . . . . . . 192

M EDICAL F ACILITIES . . . . . . . . . . . . . 193

Hospitals . . . . . . . . . . . . . . . . . . . . . 193

The Medical Rescue Campaign . . . . 193

Bodysculpt Clinics . . . . . . . . . . . . . 194

B IOETHICS . . . . . . . . . . . . . . . . . . . . . . 194

Trade in Body Parts . . . . . . . . . . . . 194

Black Market Organs . . . . . . . . . . . . 195

Playing God . . . . . . . . . . . . . . . . . . . 195

Cloning and Religion . . . . . . . 196

Fetus Farming . . . . . . . . . . 197

Eugenics . . . . . . . . . . . . . 197

DNA Profiling and

Identification . . . . . . . . 198

Genetic Testing . . . . . . . . 199

Bioroids, Parahumans,

and Uplifts . . . . . . . . . . . . . . . . . 199

Defining Who is Human . . . . . . . . . 200

Immortality . . . . . . . . . . . . . . . . . . . 200

Messing with the Environment . . . 201

Bio Law . . . . . . . . . . . . . . . . . . . . . . 201

C HARACTER T EMPLATES . . . . . . . . . . 202

Activist . . . . . . . . . . . . . . . . . . . . . . . 202

Bioengineer or Gengineer . . . . . . . 203

Biotech Executive . . . . . . . . . . . . . . 204

Ecological Engineer or Ecoteur . . 204

Epidemiologist . . . . . . . . . . . . . . . . 205

Forensic Pathologist . . . . . . . . . . . . 206

Nurse . . . . . . . . . . . . . . . . . . . . . . . . 207

Organlegger . . . . . . . . . . . . . . . . . . . 207

Physician . . . . . . . . . . . . . . . . . . . . . 208

Senior Citizen . . . . . . . . . . . . . . . . . 210

Jobs. . . . . . . . . . . . . . . . . . . . . . . . . . 210

A DVANTAGES , D ISADVANTAGES

AND S KILLS . . . . . . . . . . . . . . . . . 210

New Features . . . . . . . . . . . . . . . . . . 212

New Meta-Traits . . . . . . . . . . . . . . . 213

M ODIFIERS . . . . . . . . . . . . . . . . . . . . . . 214

New Enhancements . . . . . . . . . . . . 214

Limitations . . . . . . . . . . . . . . . . . . . 215

New Limitations . . . . . . . . . . . . . . . 215

About Our Commentators . . . . . . . 216

9. B IOTECH S ETTINGS . . . . 217

A LEXANDER A THANATOS . . . . . . . . . 217

History . . . . . . . . . . . . . . . . . . . . . . . 218

Anthropithekos . . . . . . . . . . . . . . . . . 219

The Empire . . . . . . . . . . . . . . . . . . . 220

M AP : T HE E MPIRE OF

A LEXANDER THE G REAT . . . . . . . . . 220

M AP : A LEXANDRIA . . . . . . . . . . . . . . . . 221

Technology . . . . . . . . . . . . . . . . . . . 221

Alexander Athanatos in

Infinite Worlds . . . . . . . . . . . . . . 222

Organizations . . . . . . . . . . . . . . . . . 222

Alexander Phantasia . . . . . . . . . . . . 223

Characters . . . . . . . . . . . . . . . . . . . . 223

Adventure Seeds . . . . . . . . . . . . . . . . 224

D RACONIS . . . . . . . . . . . . . . . . . . . . . . . 224

The Fleet . . . . . . . . . . . . . . . . . . . . . 224

The Sigma Draconis System . . . . . . 225

Technology . . . . . . . . . . . . . . . . . . . 225

Bioshuttle . . . . . . . . . . . . . . . . . . . . . 226

Settling In . . . . . . . . . . . . . . . . . . . . 228

Organizations . . . . . . . . . . . . . . . . . 229

Characters . . . . . . . . . . . . . . . . . . . . 229

Adventure Seeds . . . . . . . . . . . . . . . . 229

Variants . . . . . . . . . . . . . . . . . . . . . . 230

G LOSSARY . . . . . . . . . . . . . 231

B IBLIOGRAPHY . . . . . . . . . 234

I NDEX . . . . . . . . . . . . . . . 238

C ONTENTS

I NTRODUCTION

Genetic engineering and other biomedical technology

are starting to change the world in ways we can only begin

to guess at.

Can we resist the temptation to tinker with our genes

when the potential rewards include immortality? Will exot-

ic wonder drugs soon be produced in cows and goats?

Could natural or artificial plagues wipe us out, or will

biotech conquer disease or transform us into posthuman

superbeings? And just how do genetic engineering and

cloning work, anyhow?

GURPS Bio-Tech explores these and other questions,

examining the promise and perils of medical and biotech-

nologies real and imagined, and their effects on characters

and societies. The answers may surprise you . . .

David Morgan-Mar is a research engineer who lives in

Sydney, Australia. He is the author of GURPS Update and

co-author of Transhuman Space: Under Pressure, and has

contributed to several GURPS books including Monsters

and Steam-Tech.

About GURPS

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Errata. Everyone makes mistakes, including us –

but we do our best to fix our errors. Up-to-date

errata sheets for all GURPS releases, including this

book, are available on our website – see below.

Internet. Visit us on the World Wide Web at

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Bibliographies. Many of our books have exten-

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“Bibliography” link.

Using This Book

Biotechnology breeds its own jargon. While most tech-

nical terms are explained as they are introduced, if you run

into an obscure term, check the Glossary (p. 231).

Fictional quotes introduce many sections of this book.

Capsule biographies of our “commentators” appear in

Chapter 8 (p. 216).

P UBLICATION H ISTORY

This is the second edition of GURPS Bio-Tech ; it has

been revised to the GURPS Fourth Edition rules and

expanded to cover medicine, drugs, magic, and new tech-

nologies. Some variant races and wonder drugs were intro-

duced in GURPS Space (by William Barton and Steve

Jackson). The biological android (bioroid) and proteus

virus rules originated in GURPS Robots (David Pulver).

The first edition of GURPS Bio-Tech (by David Pulver) was

144 pages long and focused on modern and future technol-

ogy. Some of its fictional vignettes established ideas that

would later be expanded in the Transhuman Space series.

In turn, a few biotech and variant races in this edition are

derived from material introduced in Transhuman Space

(David Pulver) and its supplements Deep Beyond (David

Pulver), Fifth Wave (Jon F. Zeigler), and Under Pressure

(David Morgan-Mar, Kenneth Peters, and Constantine

Thomas). The biotech spells are based on those in David

Pulver’s Bio-Tech Designer Notes in Pyramid . The medical

care flowchart and some advanced medicine rules are

adapted from a Pyramid article by Eric Funk.

A BOUT THE A UTHORS

David L. Pulver is a freelance writer and game designer

who lives in Victoria, Canada. He has written or co-

authored numerous GURPS books, including GURPS

Basic Set Fourth Edition , Transhuman Space , and the

original Bio-Tech.

Rules and statistics in this book are specifically

for the GURPS Basic Set, Fourth Edition. Page ref-

erences that begin with B refer to that book, not

this one.

I NTRODUCTION

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