Engineering and Manufacturing for Biotechnology - Marcel Hofman & Philippe Thonart.pdf

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ENGINEERING AND MANUFACTURING FOR BIOTECHNOLOGY
VOLUME 4
FOCUS ON BIOTECHNOLOGY
Volume 4
Series Editors
MARCEL HOFMAN
Centre for Veterinary and Agrochemical Research, Tervuren, Belgium
JOZEF ANNÉ
Rega Institute, University of Leuven, Belgium
Volume Editors
MARCEL HOFMAN
Société de Chimie Industrielle,
Centre for Veterinary and Agrochemical Research, Tervuren, Belgium
PHILIPPE THONART
Faculté Univ. des Sciences Agronomiques Gembloux,
Centre Wallon de Biologie Industrielle, Belgium
Colophon
Focus on Biotechnology is an open-ended series of reference volumes produced by
Kluwer Academic Publishers BV in co-operation with the Branche Belge de la Société
de Chimie Industrielle a.s.b.l.
The initiative has been taken in conjunction with the Ninth European Congress on
Biotechnology. ECB9 has been supported by the Commission of the European
Communities, the General Directorate for Technology, Research and Energy of the
Wallonia Region, Belgium and J Chabert, Minister for Economy of the Brussels Capital
Region.
The series is edited by Marcel Hofman, Centre for Veterinary and Agrochemical
Research, Tervuren, and Jozef Anné, Rega Institute, University of Leuven, Belgium.
206605773.001.png
Engineering and Manufacturing
for Biotechnology
Volume 4
Edited by
MARCEL HOFMAN
Société de Chimie Industrielle,
Centre for Veterinary and Agrochemical Research, Tervuren, Belgium
and
PHILIPPE THONART
Faculté Univ. des Sciences Agronomiques Gembloux,
Centre Wallon de Biologie Industrielle, Belgium
KLUWER ACADEMIC PUBLISHERS
NEW YORK, BOSTON, DORDRECHT, LONDON, MOSCOW
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Dordrecht
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EDITORS PREFACE
Early integration of process engineering and biological research is the key for success in
industrial biotechnology. This is true as well when a selected wild-type organism is put
to work as when an organism is engineered to purpose.
Focus on Biotechnology reports on biotechnology achievements in the recent past, but
also provides a strategic view on the evolution in the next decade. The present volume
"Engineering and Manufacturing for Biotechnology" took advantage of the European
Congress on Biotechnology (Brussels, Belgium, July 11-15, 1999) : by topics handled
and by expertise of the contributors the engineering science symposia of this congress
offered just what was needed to cover this important topic.
The editors have solicited the authors of a number of outstanding contributions to
illustrate the intimate interaction between productive organism and the numerous
processing steps running from the initial inoculation to the packaged product. Upstream
processing of the feed streams, selection of medium components, product harvesting,
downstream processing and product conditioning are just a few major steps. Each step
imposes a number of important choices. Every choice is to be balanced against time to
market, profitability, safety and ecology.
It should be readily apparent from this volume that the development of a truly effective
biotechnology process requires a broad command of leading-edge engineering science,
a spark of genius, and last but not least much hard work. That is why the editors wish to
express their gratitude to all the authors of this volume, for finding the time after busy
hours at the lab, on the pilot floor or in the production plant to share their experience
and enthusiasm.
A final word of esteem is due to all those that through their devoted and outstanding
secretarial skills have made the edition of this volume possible.
Marcel Hofman
Philippe Thonart
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