Color Atlas Of Histopathology Of The Cervix Uteri.pdf

Gisela Dallenbach-Hellweg

Magnus von Knebel Doeberitz

Marcus J. Trunk

Color Atlas of Histopathology of the Cervix Uteri

Gisela Dallenbach-Hellweg

Magnus von Knebel Doeberitz

Marcus J. Trunk

Color Atlas of

Histopathology

of the Cervix Uteri

Second Edition

With 239 Figures and 4 Tables

Professor Dr. med.

Gisela Dallenbach-Hellweg

Private address:

Ludolf-Krehl-Strasse 57

D-69120 Heidelbeg

Tel. +49 -6221-471461

Dr. med. Marcus J. Trunk

Head of Pathology

MTM Laboratories AG

Im Neuenheimer Feld 583

D-69120 Heidelberg

Email: trunk@mtm-laboratories.com

Professor Dr. med.

Magnus von Knebel Doeberitz

Institute of Molecular Pathology

University of Heidelberg

Im Neuenheimer Feld 220

D-69120 Heidelberg

Email: knebel@med.uni-heidelberg.de &

mvkd@aol.com

Library of Congress Control Number: 2005926890

ISBN-10 3-540-25188-X Springer Berlin Heidelberg New York

ISBN-13 978-3-540-25188-0 Springer Berlin Heidelberg New York

1st Edition ISBN-10 3-540-52295-6 Springer Berlin Heidelberg New York

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Editor: Gabriele Schröder, Heidelberg, Germany

Desk Editor: Ellen Blasig, Heidelberg, Germany

Production: ProEdit GmbH, 69126 Heidelberg, Germany

Cover: Frido Steinen-Broo, EStudio Calamar, Spain

Typesetting: K. Detzner, 67346 Speyer, Germany

Printed on acid-free paper 24/3151 ML 5 4 3 2 1 0

Heading2

Preface to the Second Edition

The new edition of this atlas integrates all significant advances made in the past 15 years

in molecular pathology, tumor virology, and genetics of cervical cancer. It emphasizes

the importance of these advances in facilitating its pathological diagnosis and in opti-

mizing clinical management and prognosis. A new chapter on immunohistochemistry

has been added, which includes refined detection methods, e.g., the overexpression of

p16 INK4a as a molecular marker in the early differential diagnosis of premalignant le-

sions. The section on etiology and pathogenesis in human papillomavirus-induced

neoplasia has been incorporated to represent new insights into the sequences of cellu-

lar and nuclear deregulation at the molecular level. All chapters have been revised to in-

clude the newest advances and relevant experiences in how to interpret and manage

cervical disease; they are supported by the addition of 35 new microphotographic illus-

trations. The tumor nomenclature is adapted to the latest edition of the WHO classifi-

cation; the morphology code of the international classification of diseases for oncology

(ICD-O) has been added. We have also updated the list of references by adding recent

relevant publications.

Again, the staff of Springer-Verlag deserve our thanks for their patience and skill in

preparing the manuscript and in reproducing the microphotographs.

Heidelberg, February 2005

Gisela Dallenbach-Hellweg,

Magnus von Knebel Doeberitz,

and Marcus J. Trunk

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