Harvey Lodish - Molecular Cell Biology.pdf

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Book mcb. Table of Contents
Acknowledgments
About the Authors
Preface
Supplements
1. The Dynamic Cell
1.1. Evolution: At the Core of Molecular Change
1.2. The Molecules of Life
1.3. The Architecture of Cells
1.4. The Life Cycle of Cells
1.5. Cells into Tissues
1.6. Molecular Cell Biology: An Integrated View of Cells at Work
2. Chemical Foundations
2.1. Covalent Bonds
2.2. Noncovalent Bonds
2.3. Chemical Equilibrium
2.4. Biochemical Energetics
2.5. Activation Energy and Reaction Rate
Testing Yourself on the Concepts
MCAT/GRE-Style Questions
References
3. Protein Structure and Function
3.1. Hierarchical Structure of Proteins
 
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3.2. Folding, Modification, and Degradation of Proteins
3.3. Functional Design of Proteins
3.4. Membrane Proteins
3.5. Purifying, Detecting, and Characterizing Proteins
PERSPECTIVES for the Future
PERSPECTIVES in the Literature
Testing Yourself on the Concepts
MCAT/GRE-Style Questions
References
4. Nucleic Acids, the Genetic Code, and the Synthesis of Macromolecules
4.1. Structure of Nucleic Acids
4.2. Synthesis of Biopolymers: Rules of Macromolecular Carpentry
4.3. Nucleic Acid Synthesis
4.4. The Three Roles of RNA in Protein Synthesis
4.5. Stepwise Formation of Proteins on Ribosomes
PERSPECTIVES for the Future
PERSPECTIVES in the Literature
Testing Yourself on the Concepts
MCAT/GRE-Style Questions
References
5. Biomembranes and the Subcellular Organization of Eukaryotic Cells
5.1. Microscopy and Cell Architecture
5.2. Purification of Cells and Their Parts
5.3. Biomembranes: Structural Organization and Basic Functions
5.4. Organelles of the Eukaryotic Cell
PERSPECTIVES for the Future
PERSPECTIVES in the Literature
Testing Yourself on the Concepts
MCAT/GRE-Style Questions
References
6. Manipulating Cells and Viruses in Culture
6.1. Growth of Microorganisms in Culture
6.2. Growth of Animal Cells in Culture
6.3. Viruses: Structure, Function, and Uses
PERSPECTIVES for the Future
PERSPECTIVES in the Literature
Testing Yourself on the Concepts
MCAT/GRE-Style Questions
References
7. Recombinant DNA and Genomics
7.1. DNA Cloning with Plasmid Vectors
7.2. Constructing DNA Libraries with l Phage and Other Cloning Vectors
7.3. Identifying, Analyzing, and Sequencing Cloned DNA
7.4. Bioinformatics
7.5. Analyzing Specific Nucleic Acids in Complex Mixtures
7.6. Producing High Levels of Proteins from Cloned cDNAs
7.7. Polymerase Chain Reaction: An Alternative to Cloning
7.8. DNA Microarrays: Analyzing Genome-Wide Expression
PERSPECTIVES for the Future
PERSPECTIVES in the Literature
Testing Yourself on the Concepts
MCAT/GRE-Style Questions
References
8. Genetic Analysis in Cell Biology
8.1. Mutations: Types and Causes
8.2. Isolation and Analysis of Mutants
8.3. Genetic Mapping of Mutations
8.4. Molecular Cloning of Genes Defined by Mutations
8.5. Gene Replacement and Transgenic Animals
PERSPECTIVES for the Future
PERSPECTIVES in the Literature
Testing Yourself on the Concepts
MCAT/GRE-Style Questions
References
9. Molecular Structure of Genes and Chromosomes
9.1. Molecular Definition of a Gene
9.2. Chromosomal Organization of Genes and Noncoding DNA
9.3. Mobile DNA
9.4. Functional Rearrangements in Chromosomal DNA
9.5. Organizing Cellular DNA into Chromosomes
9.6. Morphology and Functional Elements of Eukaryotic Chromosomes
9.7. Organelle DNAs
PERSPECTIVES for the Future
PERSPECTIVES in the Literature
Testing Yourself on the Concepts
MCAT/GRE-Style Questions
References
10. Regulation of Transcription Initiation
10.1. Bacterial Gene Control: The Jacob-Monod Model
10.2. Bacterial Transcription Initiation
10.3. Eukaryotic Gene Control: Purposes and General Principles
10.4. Regulatory Sequences in Eukaryotic Protein-Coding Genes
10.5. Eukaryotic Transcription Activators and Repressors
10.6. RNA Polymerase II Transcription-Initiation Complex
10.7. Molecular Mechanisms of Eukaryotic Transcriptional Control
10.8. Other Transcription Systems
PERSPECTIVES for the Future
PERSPECTIVES in the Literature
Testing Yourself on the Concepts
MCAT/GRE-Style Questions
References
11. RNA Processing, Nuclear Transport, and Post-Transcriptional Control
11.1. Transcription Termination
11.2. Processing of Eukaryotic mRNA
11.3. Regulation of mRNA Processing
11.4. Signal-Mediated Transport through Nuclear Pore Complexes
11.5. Other Mechanisms of Post-Transcriptional Control
11.6. Processing of rRNA and tRNA
PERSPECTIVES for the Future
PERSPECTIVES in the Literature
Testing Yourself on the Concepts
MCAT/GRE-Style Questions
References
12. DNA Replication, Repair, and Recombination
12.1. General Features of Chromosomal Replication
12.2. The DNA Replication Machinery
12.3. The Role of Topoisomerases in DNA Replication
12.4. DNA Damage and Repair and Their Role in Carcinogenesis
12.5. Recombination between Homologous DNA Sites
PERSPECTIVES for the Future

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