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Coffee, Tea, Chocolate, and the Brain
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Coffee, Tea, Chocolate, and the Brain
Edited by
Astrid Nehlig
INSERM
Strasbourg, France
CRC PRESS
Boca Raton London New York Washington, D.C.
© 2004 by CRC Press LLC
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Library of Congress Cataloging-in-Publication Data
Coffee, tea, chocolate, and the brain / edited by Astrid Nehlig.
p. ; cm. — (Nutrition, brain, and behavior ; v. 2)
Includes bibliographical references and index.
ISBN 0-415-30691-4 (hardback : alk. paper)
1. Caffeine—Physiological effect. 2. Coffee—Physiological effect. 3. Tea—Physiological effect.
4. Chocolate—Physiological effect. 5. Neurochemistry. 6. Brain—Effect of drugs on.
[DNLM: 1. Brain—drug effects. 2. Coffee—Physiology. 3. Cacao—physiology.
4. Caffeine—pharmacology. 5. Cognition—drug effects. 6. Tea—physiology. WB 438 C674 2004]
I. Nehlig, Astrid. II. Series.
QP801.C24 C64 2004
612.8’2—dc21
2003011477
This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with
permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish
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Library of Congress Card Number 2003011477
Printed in the United States of America 1 2 3 4 5 6 7 8 9 0
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© 2004 by CRC Press LLC
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Preface
This book is the second in the series “Nutrition, Brain and Behavior.” The purpose of this series
is to provide a forum whereby basic and clinical scientists can share their knowledge and perspectives
regarding the role of nutrition in brain function and behavior. The breadth and diversity of the topics
covered in this book make it of great interest to specialists working on coffee/caffeine/tea/chocolate
research, to nutritionists and physicians, and to anyone interested in obtaining objective information
on the consequences of the consumption of coffee, tea, and chocolate on the brain.
Coffee is a very popular beverage, the second most frequently consumed after water. Likewise,
tea is a fundamental part of the diet of Asian countries and the U.K. and is becoming progressively
more popular in Western countries. Chocolate is also widely consumed all over the world. The
pleasure derived from the consumption of coffee, tea, and chocolate is accompanied by a whole
range of effects on the brain, which may explain their attractiveness and side effects. Coffee, tea,
and chocolate all contain methylxanthines, mainly caffeine, and a large part of their effects on the
brain are the result of the presence of these substances.
As part of this series on nutrition, the brain, and behavior, the present book brings new
information to the long-debated issue of the beneficial and possible negative effects on the brain
from the consumption of coffee, tea, or chocolate. Most of the book is devoted to the effects of
coffee or caffeine, which constitute the majority of the literature and research on these topics. Much
less is known about the other constituents in roasted coffee or about the effects of tea or chocolate
on the brain.
In this book, we have selected world specialists to update our knowledge on the effects of these
three methylxanthine-containing substances. Together with a collection of the data on the effects
of coffee and caffeine on sleep, cognition, memory and performance, and mood, this book contains
specific information on new avenues of research, such as the effect of caffeine on Parkinson’s
disease, ischemia, and seizures, and on the mostly unknown effects of the chlorogenic acids found
in coffee. The effects of caffeine on the stress axis and development of the brain are also updated.
Finally, the potential for addiction to coffee, caffeine, and chocolate is debated, as well as both the
possible headache-inducing effect of chocolate consumption and the alleviating effect of caffeine
on various types of headaches.
Altogether, these updates and new findings are reassuring and rather positive, showing again
that moderate coffee, tea, or chocolate consumption has mostly beneficial effects and can contribute
to a balanced and healthy diet.
We would like to take this opportunity to thank all the authors for their excellent contributions
and cooperation in the preparation of this book.
Astrid Nehlig, Ph.D.
Strasbourg, France
Editor
Chandan Prasad, Ph.D.
New Orleans, Louisiana, USA
Series Editor
© 2004 by CRC Press LLC
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Editor
earned a master’s degree in physiology and two Ph.D. degrees in physiology
and functional neurochemistry from the scientific University of Nancy, France. She is a research
director at the French Medical Research Institute, INSERM, in Strasbourg. Her main research
interests are brain metabolism, brain development, the effects of coffee and caffeine on the brain,
and temporal lobe epilepsy. She has authored or co-authored approximately 200 articles, books,
and book chapters and has been invited to deliver more than 50 lectures at international meetings
and research centers. She has received several grants for her work, mainly from the Medical
Research Foundation, NATO, and private companies, and a 2002 award from the American
Epilepsy Society.
Dr. Nehlig has spent two years in the United States working in a highly recognized neuroimaging
laboratory at the National Institute for Mental Health in Bethesda, Maryland. She has led an
INSERM research team of 10 to 15 persons for 20 years, resulting in the education of more than
15 Ph.D. students and several postdoctoral fellows. She is on the editorial board of the international
journal
and is a member of the commission of neurobiology of the International League
Against Epilepsy and of the French Society of Cerebral Blood Flow and Metabolism. She is also
the scientific advisor of PEC (Physiological Effects of Coffee), the European Scientific Association
of the Coffee Industry. She acts as an expert for numerous scientific journals and international
societies, such as NATO, the British Wellcome Trust, and the Australian Medical Research Institute.
© 2004 by CRC Press LLC
Astrid Nehlig, Ph.D.,
Epilepsia
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