Proteolytic Enzymes, Aspartic and Metallo Peptidases [Methods in Enzymology 248] - A. Barrett (AP, 1995) WW.pdf - Bio Med 22 - Aivree

Preface

Through the earlier, general volumes on proteolytic enzymes (Vol-

umes 19, 45, and 80), Methods in Enzymology made available over 200

authoritative articles on these enzymes and their inhibitors. Since the

appearance of the latest of these volumes, however, there have been

many profound advances in this field of study. The biomedical importance

of proteolytic enzymes, suspected for so long, has been established be-

yond reasonable doubt for a number of groups, including the matrix me-

talloproteinases, the viral polyprotein-processing enzymes, and the pro-

hormone-processing peptidases. The more recent, specialized Volumes

222, 223, and 241 have dealt with some of these areas, but others have

remained to be covered.

The resurgence of excitement about proteolytic enzymes has inevita-

bly resulted in an information explosion, but some of the new understand-

ing has also helped us develop novel approaches to the management of the

mass of data. As a result, we can now "see the forest for the trees" a little

more clearly. Like other proteins, the proteolytic enzymes have benefited

from the recent advances in molecular biology, and amino acid sequences

are now available for many hundreds of them. These can be used to group

the enzymes in families of evolutionarily related members. Also, there

has been a major overhaul of the recommended nomenclature for pepti-

dases by the International Union of Biochemistry and Molecular Biology.

In Volume 244 on peptidases of serine and cysteine type and in this

volume on aspartic, metallo, and other peptidases, the chapters on spe-

cific methods, enzymes, and inhibitors are organized within the rational

framework of the new systems for classification and nomenclature.

The peptidases of the aspartic and metallo types dealth with in this

volume depend for their activity on the nucleophilic activity of an ionized

water molecule, unlike the enzymes, described in Volume 244, in which

the nucleophilic character of a serine or cysteine residue is at the heart of

the catalytic mechanism. A wide variety of specificities of peptide bond

hydrolysis is represented in each set of peptidases, together with an

equally wide range of biological functions.

ALAN J. BARRETT

Contributors to Volume 248

Article numbers are in parentheses following the names of contributors.

Affiliations listed are current.

JACQUES BOUVIER (37), Animal Health De-

partment, Ciba-Geigy Ltd., CH-1566 St.

Aubin, Switzerland

MOLLY A. BROWN (32), Department of BiD-

chemistry, Strangeways Research Labo-

ratory,

ANGELA ANASTASI (43), Department of Pa-

thology, The Medical School, St. Luke's

Hospital, Msida, Malta

DAVID S. AULD (14), Center for Biochem-

ical and Biophysical Sciences and Medi-

cine, and Department of Pathology, Har-

vard Medical School and Brigham and

Women's Hospital, Boston,

Cambridge

CB1 4RN,

United

Kingdom

MICHAEL BRUNNER (46), Institut fiir Phy-

siologische Chemie, Universitiit Miin-

chen, D-80336 Miinchen 2, Germany

DAVID J. BUTTLE (4), Department of BiD-

chemistry, Strangeways Research Labo-

ratory,

Massachu-

setts 02115

HI~LRN BARELLI (36), Institat de Pharma-

cologie Moldculaire et Cellulaire, CNRS,

Universitd

Nice-Sophia

Antipolis,

F-06560 Valbonne, France

ALAN J. BARRETT (7, 13, 32, 43), Depart-

ment of Biochemistry, Strangeways Re-

search Laboratory, Cambridge CB1 4RN,

United Kingdom

ANDREW B. BECKER (44), Department of

Molecular Pharmacology, Stanford Uni-

versity

Cambridge

CBI 4RN,

United

Kingdom

PAUL CANNON (25), Institute of Biochemis-

try and Cell Biology, Syntex Discovery

Research, Paid Alto, California 94303

NIAMH X. CAWLEY (9), Laboratory of

Developmental Neurobiology, National

Institute of Child Health and Human De-

velopment, N1H and Department of

Biochemistry, Uniformed Services, Uni-

versity of the Health Sciences, Bethesda,

Maryland 20892

FRI~DI~RIC CHECLER (36), lnstitut de Phar-

macologie Moleculaire et Cellulaire,

CNRS, UniversiN de Nice-Sophia Anti-

pulis, F-06560 Valbonne, France

VALI~RIE CHESNEAU (45), Laboratoire de

Biochimie des Signaux R~gulateurs, Cel-

lulair et Mol~culaires, Unitd de Recher-

ches Associ~e au Centre National de la

Scientifique, Universitd Pierre et Marie

Curie, 75006 Paris, France

PAUL COHEN (45), Laboratoire de Biochi-

mie des Signaux Rdgulateurs, Cellulair et

Mol#culaires, Unitd de Recherches Asso-

cide au Centre National de la Scientifi-

que, Universitd Pierre et Marie Curie,

75006 Paris, France

School of Medicine,

Stanford,

California 94305

JUDD BERMAN (3), Department of Medici-

nal Chemistry, Glaxo Inc. Research Insti-

tute, Research Triangle Park, North Car-

olina 27709

D. MARK BICKETT (3), Department of Bio-

chemistry, Glaxo Inc. Research Institute,

Research Triangle Park, North Carolina

27709

JOSEPH G. BIETH (5), INSERM Unitd 392,

Laboratoire

d'Enzymologie,

Universitd

Louis Pasteur de Strasbourg,

F-67400

Illkirch, France

J6N B. BJARNASON (21, 22), The Science In-

stitute, University of lceland, IS-107 Rey-

kjavik, Iceland

JUDITH S. BOND (20), Department of Bio-

chemistry and Molecular Biology, Col-

lege of Medicine, Pennsylvania State

University, Hershey, Pennsylvania 17033

CONTRIBUTORS TO VOLUME 248

MARIE-CLAUDE FOURNII~-ZALUSKI (17),

D~partement de Pharmacochimie Mol~-

culaire et Structurale, Institut National

de la Sante et de la Recherche Medicale,

Universit~ Rend Descartes,

CHRISTOPHER A. CONLIN (34), Department

of Biological Sciences, Mankato State

University, Mankato, Minnesota 56002

PIERI~E CORVOL (18), lnstitut National de la

Sant~ et de la Recherche Medicale, Col-

ldge de France, 75005 Paris, France

THOMAS CRABBE (28), Celltech Therapeu-

tics Ltd., Slough SL1 4EN, United King-

dom

PHILIPPE CRINE (17), D~partement de Bio-

chimie, Facult~ de Mddecine, Universitd

de Montrdal, Montrdal, Canada H3C 3J7

PAMELA M. DANDO (32), Department of

Biochemistry,

75270 Paris

Cedex 06, France

JAY W. Fox (21, 22), Department of Micro-

biology, University of Virginia, Health

Sciences Center, Charlottesville, Virginia

22908

URSULA GEUSS (51), Boehringer Mannheim

GmbH, D-68305 Mannheim, Germany

PAUL GLYNN (23), Medical Research Coun-

cil Toxicology Unit, University of Leices-

ter, Leicester LE1 9HN, United Kingdom

MICHAEL GREEN (3), Department of Medic-

inal Chemistry, Glaxo Inc. Research In-

stitute, Research Triangle Park, North

Carolina 27709

MARIE-LuISE HAGMANN (51), Boehringer

Mannheim GmbH, D-82372 Penzberg,

Germany

CHRISTOPHER J. HANDLEY (4), Department

of Biochemistry and Molecular Biology,

Monash

Strangeways

Research

Laboratory,

Cambridge

CB1

4RN,

United Kingdom

PASCALE DAUCH (36), Institut de Pharma-

cologie Moleculaire et Cellulaire, CNRS,

Universitd

Nice-Sophia

Antipolis,

1:-06560 Valbonne, France

PETER A. DEDDISH (41), Departments of

Pharmacology and Anesthesiology, Uni-

versity of Illinois College of Medicine,

Chicago, Illinois 60612

MARIANNA DIOSZEGI (25), Institute of Bio-

chemistry and Cell Biology, Syntex Dis-

covery Research, Palo Alto, California

94303

VINCENT DIVE (36), D~partment d'lng~-

nierie et d'Etude des Prot~ines, C.E.N. de

Saclay, Laboratoire de Structure des Pro-

tdines

University,

Clayton

Victoria

3168, Australia

Louis B. HERSH (16), Department of Bio-

chemistry, College of Medicine, Univer-

sity of Kentucky, Lexington,

Kentucky

40536

LINDA HOWARD (23), Department of Cell

Biology and Lombardi Cancer Center,

Georgetown University School of Medi-

cine, Washington 20007

GRAZIA ISAYA (33), Department of Genet-

ics, Yale University School of Medicine,

New Haven, Connecticut 06510

KARL E. KADLER (49, 50), Department of

Biological Sciences, Research Division of

Biochemistry, University of Manchester,

Manchester M13 9PT, United Kingdom

TAKASHI KAGEYAMA (8), Department of

Cellular and Molecular Biology, Primate

Research Institute, Kyoto University, In-

uyama, Aichi 484, Japan

FRANTISEK KALOUSEK (33), Department of

Genetics, Yale University School of Medi-

cine, New Haven, Connecticut 06510

Solution,

91191 GiflYvette,

France

ROBERT ETGES (37), Department of Bio-

chemistry, University of Puerto Rico, San

Juan, Puerto Rico 00936

STEPHAN FISCHER (51), Boehringer Mann-

heim GmbH, D-82372 Penzberg,

Ger-

many

THIERRY FOULON (45), Laboratoire de Bio-

chimie des Signaux R~gulateurs, Cellulair

et Mol~culaires, Unit~ de Recherches As-

soci~e au Centre National de la Scientifi-

que, Universit~ Pierre et Marie Curie,

75006 Paris, France

CONTRIBUTORS TO VOLUME 248

CHIH-MIN KAM (1), School of Chemistry

and Biochemistry, Georgia Institute of

Technology, Atlanta, Georgia 30332

EERAT KESSLER (48), Maurice and Gabriela

Goldschleger Eye Research Institute,

Sackler Faculty of Medicine, Tel-Aviv

University, Tel-Hashomer 52621, Israel

C. GRAHAM KNIGHT (2, 6, 32), Department

of Cell Adhesion and Signalling, Strange-

ways Research Laboratory, Cambridge

CB1 4RN, United Kingdom

GEORG-B URKHARD KRESSE (51), Boehringer

Mannheim

ALAN MELLORS (47), Department of Chem-

istry and Biochemistry, Guelph-Waterloo

Centre for Graduate Work in Chemistry,

University of Guelph, Guelph, Ontario,

Canada NIG 2W1

CHARLES G. MILLER (34), Department of

Microbiology, University ofIllinois at Ur-

bana-Champaign, Urbana, Illinois 61801

VI~RONIQUE MONNET (35), 1NRA Centre De

Recherches De Jouy-en-Josas, Station De

Recherches

Laitidres,

Domaine

Vilvert,

78352 Jouy-en-Josas,

Cedex,

GmbH,

D-82372 Penzberg,

France

CESARE MONTECUCCO (39), Centro CNR

Biomembrane and Dipartimento di

Scienze Biomediche, Universita di Pa-

dora, 75-35100Padova, Italy

KAZUYUKI MORIHARA (15)~ Institute of Ap-

plied Life Sciences, Graduate School,

University of East Asia, Yamaguchi 751,

Japan

GILLIAN MURPHY (28, 30), Department of

Cell and Molecular Biology, Strangeways

Research Laboratory,

Germany

CHINGWEN LI (16), Department of Bio-

chemistry, College of Medicine, Univer-

sity of Kentucky, Lexington, Kentucky

40536

SAMANTHA J. LIGHTFOOT (49), Department

ofBiological Sciences, Research Division

of Biochemistry, University of Manches-

ter, Manchester M13 9PT, United King-

dom

XINLI LIN (11), Protein Studies Program,

Oklahoma Medical Research Founda-

tion, Oklahoma City, Oklahoma 73104

REGGIE Y.C. LO (47), Department of Micro-

biology, University of Guelph, Guelph,

Ontario, Canada N1G 2W1

Y. PENG LOH (9), Section on Cellular Neu-

robiology, Laboratory of Developmental

Neurobiology, National Institute of Child

Health and Human Development, and

Department of Biochemistry, Uniformed

Services, University of the Health Sci-

ences, Bethesda, Maryland 20892

HIROSHI MAEDA (24), Department ofMicro-

biology, Kumamoto University Medical

School, Kumamoto 860, Japan

GERARD M. MCGEEHAN (3), Department of

Biochemistry, Glaxo Inc. Research Labo-

ratories, Research Triangle Park, North

Carolina 27709

NORMAN McKIE (32), Department of Bio-

chemistry, Strangeways Research Labo-

ratory, Cambridge CB1 4RN,

Cambridge CB1

4RN, United Kingdom

HIDEAKI NAGASE (27), Department of Bio-

chemistry and Molecular Biology, Uni-

versity of Kansas Medical Center, Kan-

sas City, Kansas 66160

WALTER NEUPERT (46), Institut fiir Phy-

siologische Chemie, Universit~it Miin-

chen, D-80336 Miinchen 2, Germany

FLORENCE NOBLE (17), D~partement de

Pharmacochimie Molgcalaire et Strac-

turale, Institut National de la Sante et de

la Recherche Medicale, Centre, National

de la Recherche Scientifique, Universitg

Rend Descartes, 75270 Paris Cedex 06,

France

ADRIAN R. PIEROTTI (45), Department of

Biological Sciences, Glasgow Caledonian

University, Glasgow GL4 OBA, Scotland

ANDREW G. PLAUT (38), Department of

Medicine, Gastroenterology Division,

Tufts University School of Medicine and

New England Medical Center, Boston,

Massachusetts 02111

United

Kingdom

xii

CONTRIBUTORS TO VOLUME 248

JAMES C. POWERS (1), School of Chemistry

and Biochemistry, Georgia Institute of

Technology, Atlanta, Georgia 30332

ANNIK PRAT (45), Laboratoire de Biochimie

des Signaux Rdgulateurs, Cellulair et Mo-

Idculaires, Unitd de Recherches Associde

au Centre National de la Scientifique,

Universitd Pierre et Marie Curie, 75006

Paris, France

NEIL D. RAWLINCS (7, 13, 32), Department

of Biochemistry, Strangeways Research

Laboratory,

WALTER STOCKER (19), Zoologisches lnsti-

tut der Universitiit Heidelberg, Physiolo-

gie, Im Neuenheimer FeN, D-69120 Hei-

delberg, Germany

KENJI TAKAHASHI (10), Department of Bio-

physics and Biochemistry, Faculty of Sci-

ence, The University of Tokyo, Tokyo 113,

Japan

FULONG TAN (41), Departments of Pharma-

cology and Anesthesiology, University of

Illinois College ofMedicine, Chicago, Illi-

nois 60612

JORDAN TANG (11), Oklahoma Medical Re-

search Foundation, Protein Studies Pro-

gram, Oklahoma City, Oklahoma 73104

HARALD TSCHESCHE (26), Biochemistry De-

partment, University Bielefeld, D-33615,

Bielefeld Germany

HAROLD E. VAN WART (25), Institute of

Biochemistry and Cell Biology, Syntex

Discovery Research, PaiD Alto, Califor-

nia 94303

BRUNO VINCENT (36), Institut de Pharma-

cologie Moldculaire et Cellulaire, CNRS,

Universitd

Cambridge

CB1

4RN,

United Kingdom

BERNARD P. ROQUES (17), Ddpartement de

Pharmacochimie Moldculaire et Struc-

turale, Institut National de la Santd et de

la Recherche Medicale, Centre National

de la Recherche Scientifique, Unioersitd

Rend Descartes, 75270 Paris Cedex 06,

France

RICHARD A. ROTH (44), Department of Mo-

lecular Pharmacology, Stanford Univer-

sity School of Medicine, Stanford, Cali-

fornia 94305

KRISHNAN SANKARAN (12), Department of

Microbiology and Immunology, Uni-

formed Services, University of the Health

Sciences, Bethesda, Maryland 20814

GIAMPIETRO SCHIAVO (39), Centro CNR

Biomembrane and Dipartimento di

Scienze Biomediche, Universitd di Pa-

dora, 75-35100Padova, Italy

PASCAL SCHNEIDER (37), Department of

Biochemistry, University of Dundee,

Dundee DD1 4HN, Scotland

ATSUSHI SERIZAWA (32), Sapporo Research

Laboratory, Snow Brand Milk Products

Co., Ltd., Sapporo 065, Japan

RANDAL A. SKIDGEL (40, 41), Department

of Pharmacology and Anesthesiology,

University oflllinois College of Medicine,

Chicago, Illinois 60612

FLORENT SOUBRIER (18), Institut National

de la Santd et de la Recherche Medicale,

Colldge de France, 75005Paris, France

VALENTIN M. STEPANOV (42), Protein

Chemistry Laboratory, Institute ofMicro-

bial Genetics, Moscow 113545,

Russia

Nice-Sophia

Antipolis,

F-06560 Valbonne, France

JEAN PIERRE VINCENT (36), Institut de

Pharmacologie Moldculaire et Cellulaire,

CNRS, Universitd de Nice-Sophia Anti-

polls, F-06560 Valbonne, France

ROD B. WATSON (49), Department of Bio-

logical Sciences, Research Division of

Biochemistry, University of Manchester,

Manchester M13 9PT, United Kingdom

FRANCES WILLENBROCK (30), Department

of Biochemistry, Queen Mary and West-

field College, University of London, Lon-

don E1 4NS, United Kingdom

TRAcY A. WILLIAMS (18), Institut National

de la Santd et de la Recherche Medicale,

Colldge de France, 75005 Paris, France

JEFFREY S. WISEMAN (3), Department of

Biochemistry, Glaxo Inc. Research Insti-

tute, Research Triangle Park, North Car-

olina 27709

J. FREDERICK WOESSNER, JR. (29, 31), De-

partment of Biochemistry and Molecular

Biology, University of Miami, School of

Medicine, Miami, Florida 33101

Proteolytic Enzymes, Aspartic and Metallo Peptidases [Methods in Enzymology 248] - A. Barrett (AP, 1995) WW.pdf

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