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D
IABETES AND
C
ARDIOVASCULAR
D
ISEASE
S
ECOND
E
DITION
C
ONTEMPORARY
C
ARDIOLOGY
C
HRISTOPHER
P. C
ANNON
,
MD
S
ERIES
E
DITOR
Diabetes and Cardiovascular Disease,
Second
Edition,
edited by
Michael T. Johnstone,
MD
,
CM
,
FRCP
(
C
) and Aristidis Veves,
MD
,
DS
c
, 2005
Cardiovascular Disease in the Elderly
,
edited by
Gary Gerstenblith,
MD
, 2005
Platelet Function:
Assessment, Diagnosis, and
Treatment,
edited by
Martin Quinn,
MB BC
h
BAO
,
P
h
D
and Desmond Fitzgerald,
MD
,
FRCPI
, 2005
Angiogenesis and Direct Myocardial
Revascularization,
edited by
Roger J. Laham,
MD
and Donald S. Baim,
MD
, 2005
Interventional Cardiology:
Percutaneous
Noncoronary Intervention,
edited by
Howard
C. Herrmann,
MD
, 2005
Principles of Molecular Cardiology
,
edited by
Marschall S. Runge,
MD
and Cam Patterson,
MD
, 2005
Heart Disease Diagnosis and Therapy:
A Practical
Approach, Second Edition,
edited by
M.
Gabriel Khan,
MD
,
FRCP
,
FRCP
(
C
),
FACC
, 2005
Cardiovascular Genomics:
Gene Mining for
Pharmacogenomics and Gene Therapy,
edited by
Mohan K. Raizada,
P
h
D
, Julian F.
R. Paton,
P
h
D
, Michael J. Katovich,
P
h
D
, and
Sergey Kasparov,
MD
,
P
h
D
, 2005
Surgical Management of Congestive Heart
Failure
,
edited by
James C. Fang,
MD
and Gregory S. Couper,
MD
, 2005
Cardiopulmonary Resuscitation
,
edited by
Joseph
P. Ornato,
MD
,
FAP
,
FACC
and Mary Ann
Peberdy,
MD
,
FACC
, 2005
CT of the Heart:
Principles and Applications,
edited by
U. Joseph Schoepf,
MD
, 2005
Heart Disease and Erectile Dysfunction
,
edited by
Robert A. Kloner,
MD
,
P
h
D
, 2004
Cardiac Transplantation:
The Columbia
University Medical Center/New York-
Presbyterian Hospital Manual,
edited by
Niloo M. Edwards,
MD
, Jonathan M. Chen,
MD
and Pamela A. Mazzeo, 2004
Coronary Disease in Women:
Evidence-Based Diag-
nosis and Treatment,
edited by
Leslee J. Shaw,
P
h
D
and Rita F. Redberg,
MD
,
FACC
, 2004
Complementary and Alternate Cardiovascular
Medicine,
edited by
Richard A. Stein,
MD
and Mehmet C. Oz,
MD
, 2004
Nuclear Cardiology, The Basics:
How to Set Up
and Maintain a Laboratory,
by
Frans J. Th.
Wackers,
MD
,
P
h
D
, Wendy Bruni,
BS
,
CNMT
,
and Barry L. Zaret,
MD
, 2004
Minimally Invasive Cardiac Surgery,
Second
Edition,
edited by
Daniel J. Goldstein,
MD
and Mehmet C. Oz,
MD
2004
Cardiovascular Health Care Economics,
edited
by
William S. Weintraub,
MD
, 2003
Platelet Glycoprotein IIb/IIIa Inhibitors in
Cardiovascular Disease,
Second Edition,
edited by
A. Michael Lincoff,
MD
, 2003
Heart Failure:
A Clinician’s Guide to Ambulatory
Diagnosis and Treatment,
edited by
Mariell
L. Jessup,
MD
and Evan Loh,
MD
, 2003
Management of Acute Coronary Syndromes,
Second Edition,
edited by
Christopher P.
Cannon,
MD
2003
Aging, Heart Disease, and Its Management:
Facts and Controversies,
edited by
Niloo
M. Edwards,
MD
, Mathew S. Maurer,
MD
,
and Rachel B. Wellner,
MPH
, 2003
Peripheral Arterial Disease:
Diagnosis and
Treatment,
edited by
Jay D. Coffman,
MD
and Robert T. Eberhardt,
MD
, 2003
Cardiac Repolarization:
Bridging Basic and
Clinical Science,
edited by
Ihor Gussak,
MD
,
P
h
D
, Charles Antzelevitch,
P
h
D
, Stephen C.
Hammill,
MD
, Win K. Shen,
MD
, and Preben
Bjerregaard,
MD
,
DMS
c, 2003
Essentials of Bedside Cardiology:
With
a Complete Course in Heart Sounds and
Murmurs on CD, Second Edition,
by
Jules
Constant,
MD
, 2003
Primary Angioplasty in Acute Myocardial Infarc-
tion,
edited by
James E. Tcheng,
MD
, 2002
Cardiogenic Shock:
Diagnosis and Treatment,
edited by
David Hasdai,
MD
, Peter B.
Berger,
MD
, Alexander Battler,
MD
, and
David R. Holmes, Jr.,
MD
, 2002
Management of Cardiac Arrhythmias,
edited by
Leonard I. Ganz,
MD
, 2002
Diabetes and Cardiovascular Disease,
edited by
Michael T. Johnstone,
MD
and Aristidis
Veves,
MD
,
DS
c
, 2001
D
IABETES
AND
C
ARDIOVASCULAR
D
ISEASE
Second Edition
Edited by
M
ICHAEL
T. J
OHNSTONE
,
MD
,
CM
,
FRCP
(
C
)
A
RISTIDIS
V
EVES
,
MD
,
DS
c
Beth Israel Deaconess Medical Center, Harvard Medical School,
Boston, MA
© 2005 Humana Press Inc.
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Totowa, New Jersey 07512
humanapress.com
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by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission
from the Publisher.
The content and opinions expressed in this book are the sole work of the authors and editors, who have warranted due
diligence in the creation and issuance of their work. The publisher, editors, and authors are not responsible for errors
or omissions or for any consequences arising from the information or opinions presented in this book and make no
warranty, express or implied, with respect to its contents.
Due diligence has been taken by the publishers, editors, and authors of this book to assure the accuracy of the information
published and to describe generally accepted practices. The contributors herein have carefully checked to ensure that
the drug selections and dosages set forth in this text are accurate and in accord with the standards accepted at the time
of publication. Notwithstanding, as new research, changes in government regulations, and knowledge from clinical
experience relating to drug therapy and drug reactions constantly occurs, the reader is advised to check the product
information provided by the manufacturer of each drug for any change in dosages or for additional warnings and
contraindications. This is of utmost importance when the recommended drug herein is a new or infrequently used drug.
It is the responsibility of the treating physician to determine dosages and treatment strategies for individual patients.
Further it is the responsibility of the health care provider to ascertain the Food and Drug Administration status of each
drug or device used in their clinical practice. The publisher, editors, and authors are not responsible for errors or
omissions or for any consequences from the application of the information presented in this book and make no warranty,
express or implied, with respect to the contents in this publication.
Production Editor: Melissa Caravella
Cover design by Patricia F. Cleary
Cover Illustration: From Fig. 2 in Chapter 22, "Peripheral Vascular Disease in Patients With Diabetes Mellitus," by
Bernadette Aulivola, Allen D. Hamdan, and Frank W. LoGerfo.
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of the Transactional Reporting Service is: [0-58829-413-7/05 $30.00].
Printed in the United States of America. 10 9 8 7 6 5 4 3 2 1
eISBN: 1-59259-908-7
Library of Congress Cataloging-in-Publication Data
Diabetes and cardiovascular disease / edited by Michael T. Johnstone and
Aristidis Veves.-- 2nd ed.
p. cm. -- (Contemporary cardiology)
Includes bibliographical references and index.
ISBN 1-58829-413-7 (alk. paper)
1. Diabetic angiopathies. 2. Cardiovascular system--Diseases--Etiology.
I. Johnstone, Michael T. II. Veves, Aristidis. III. Series: Contemporary
cardiology (Totowa, N.J. : unnumbered)
RC700.D5D524 2005
616.4'62--dc22
2005000629
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