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D IABETES AND C ARDIOVASCULAR D ISEASE
S ECOND E DITION
C ONTEMPORARY C ARDIOLOGY
C HRISTOPHER P. C ANNON , MD
S ERIES E DITOR
Diabetes and Cardiovascular Disease, Second
Edition, edited by Michael T. Johnstone, MD ,
CM , FRCP ( C ) and Aristidis Veves, MD , DS c , 2005
Cardiovascular Disease in the Elderly , edited by
Gary Gerstenblith, MD , 2005
Platelet Function: Assessment, Diagnosis, and
Treatment, edited by Martin Quinn, MB BC h BAO ,
P h D and Desmond Fitzgerald, MD , FRCPI , 2005
Angiogenesis and Direct Myocardial
Revascularization, edited by Roger J. Laham,
MD and Donald S. Baim, MD , 2005
Interventional Cardiology: Percutaneous
Noncoronary Intervention, edited by Howard
C. Herrmann, MD , 2005
Principles of Molecular Cardiology , edited by
Marschall S. Runge, MD and Cam Patterson,
MD , 2005
Heart Disease Diagnosis and Therapy: A Practical
Approach, Second Edition, edited by M.
Gabriel Khan, MD , FRCP , FRCP ( C ), FACC , 2005
Cardiovascular Genomics: Gene Mining for
Pharmacogenomics and Gene Therapy,
edited by Mohan K. Raizada, P h D , Julian F.
R. Paton, P h D , Michael J. Katovich, P h D , and
Sergey Kasparov, MD , P h D , 2005
Surgical Management of Congestive Heart
Failure , edited by James C. Fang, MD
and Gregory S. Couper, MD , 2005
Cardiopulmonary Resuscitation , edited by Joseph
P. Ornato, MD , FAP , FACC and Mary Ann
Peberdy, MD , FACC , 2005
CT of the Heart: Principles and Applications,
edited by U. Joseph Schoepf, MD , 2005
Heart Disease and Erectile Dysfunction , edited by
Robert A. Kloner, MD , P h D , 2004
Cardiac Transplantation: The Columbia
University Medical Center/New York-
Presbyterian Hospital Manual, edited by
Niloo M. Edwards, MD , Jonathan M. Chen,
MD and Pamela A. Mazzeo, 2004
Coronary Disease in Women: Evidence-Based Diag-
nosis and Treatment, edited by Leslee J. Shaw,
P h D and Rita F. Redberg, MD , FACC , 2004
Complementary and Alternate Cardiovascular
Medicine, edited by Richard A. Stein, MD
and Mehmet C. Oz, MD , 2004
Nuclear Cardiology, The Basics: How to Set Up
and Maintain a Laboratory, by Frans J. Th.
Wackers, MD , P h D , Wendy Bruni, BS , CNMT ,
and Barry L. Zaret, MD , 2004
Minimally Invasive Cardiac Surgery, Second
Edition, edited by Daniel J. Goldstein, MD
and Mehmet C. Oz, MD 2004
Cardiovascular Health Care Economics, edited
by William S. Weintraub, MD , 2003
Platelet Glycoprotein IIb/IIIa Inhibitors in
Cardiovascular Disease, Second Edition,
edited by A. Michael Lincoff, MD , 2003
Heart Failure: A Clinician’s Guide to Ambulatory
Diagnosis and Treatment, edited by Mariell
L. Jessup, MD and Evan Loh, MD , 2003
Management of Acute Coronary Syndromes,
Second Edition, edited by Christopher P.
Cannon, MD 2003
Aging, Heart Disease, and Its Management:
Facts and Controversies, edited by Niloo
M. Edwards, MD , Mathew S. Maurer, MD ,
and Rachel B. Wellner, MPH , 2003
Peripheral Arterial Disease: Diagnosis and
Treatment, edited by Jay D. Coffman, MD
and Robert T. Eberhardt, MD , 2003
Cardiac Repolarization: Bridging Basic and
Clinical Science, edited by Ihor Gussak, MD ,
P h D , Charles Antzelevitch, P h D , Stephen C.
Hammill, MD , Win K. Shen, MD , and Preben
Bjerregaard, MD , DMS c, 2003
Essentials of Bedside Cardiology: With
a Complete Course in Heart Sounds and
Murmurs on CD, Second Edition, by Jules
Constant, MD , 2003
Primary Angioplasty in Acute Myocardial Infarc-
tion, edited by James E. Tcheng, MD , 2002
Cardiogenic Shock: Diagnosis and Treatment,
edited by David Hasdai, MD , Peter B.
Berger, MD , Alexander Battler, MD , and
David R. Holmes, Jr., MD , 2002
Management of Cardiac Arrhythmias, edited by
Leonard I. Ganz, MD , 2002
Diabetes and Cardiovascular Disease, edited by
Michael T. Johnstone, MD and Aristidis
Veves, MD , DS c , 2001
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D IABETES
AND C ARDIOVASCULAR
D ISEASE
Second Edition
Edited by
M ICHAEL T. J OHNSTONE , MD , CM , FRCP ( C )
A RISTIDIS V EVES , MD , DS c
Beth Israel Deaconess Medical Center, Harvard Medical School,
Boston, MA
86727521.003.png
© 2005 Humana Press Inc.
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Production Editor: Melissa Caravella
Cover design by Patricia F. Cleary
Cover Illustration: From Fig. 2 in Chapter 22, "Peripheral Vascular Disease in Patients With Diabetes Mellitus," by
Bernadette Aulivola, Allen D. Hamdan, and Frank W. LoGerfo.
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Printed in the United States of America. 10 9 8 7 6 5 4 3 2 1
eISBN: 1-59259-908-7
Library of Congress Cataloging-in-Publication Data
Diabetes and cardiovascular disease / edited by Michael T. Johnstone and
Aristidis Veves.-- 2nd ed.
p. cm. -- (Contemporary cardiology)
Includes bibliographical references and index.
ISBN 1-58829-413-7 (alk. paper)
1. Diabetic angiopathies. 2. Cardiovascular system--Diseases--Etiology.
I. Johnstone, Michael T. II. Veves, Aristidis. III. Series: Contemporary
cardiology (Totowa, N.J. : unnumbered)
RC700.D5D524 2005
616.4'62--dc22
2005000629
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